Article
Growth suppression of normal mammary epithelial cells by wild-type p53.
Oncogene - 1 Feb 1994
Merlo G R, Venesio T, Taverna D, Marte B M, Callahan R, Hynes N E
Abstract excerpt
p53 mutations are frequent in human breast cancer. In order to understand the role of p53 in the context of the accumulation of mutations in breast cancer, a model of non transformed mammary cells was sought. The HC11 cells are immortalized, non transformed rodent mammary epithelial cells which synthesize milk proteins following stimulation with lactogenic hormones. p53 protein was readily detected in HC11...
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