Article
Molecular events in radiation transformation.
Radiation research - 1 Jan 2001
Syljuåsen R G, Krolewski B, Little J B
Abstract excerpt
Studies of human tumor cell lines have revealed alterations in the regulation of a number of cell cycle-related genes, associated in some cases with a TP53-independent loss of the radiation-induced G(1)-phase arrest. It is not clear, however, whether these are early or late events in tumor development, or they arise in tumor cell lines during growth in culture. Since the oncogenic transformation of an individual...
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Fibroblasts
- G1 Phase
- Genes, cdc
- Genes, p53
- Mice
- Mice, Inbred C3H
- Mutation
- Neoplasms, Radiation-Induced
- Tumor Suppressor Protein p53