Article
Effects of p53 mutations on cellular sensitivity to ionizing radiation.
American journal of clinical oncology - 1 Oct 2001
Matsui Y, Tsuchida Y, Keng P C
Abstract excerpt
Mutations in the p53 tumor suppressor gene have been found in more than 50% of human tumors including those in breast, colon, lung, and oral cavity. However, the significance of p53 mutation in radiation sensitivity and its underlying mechanisms still remains unclear. In this study, we have measured the effects of p53 mutation on cell cycle delay, apoptosis, and radiation sensitivity using mouse cells transfected...
Topics
- Animals
- Apoptosis
- Cell Cycle
- Cell Line
- Cell Survival
- Fibroblasts
- Genes, p53
- Mice
- Mutation
- Radiation Tolerance
- Radiation, Ionizing
- Transfection