Article
Specific TP53 mutation pattern in radiation-induced sarcomas.
Carcinogenesis - 1 Jun 2006
Gonin-Laurent Nathalie, Gibaud Anne, Huygue Mathilde, Lefèvre Sandrine H, Le Bras Morgane, Chauveinc Laurent, Sastre-Garau Xavier, Doz François, Lumbroso Livia, Chevillard Sylvie, Malfoy Bernard
Abstract excerpt
The mutagenic properties of ionizing radiation are well known, but the presence of specific mutations in human radiation-induced tumours is not established. We have studied a series of 36 secondary sarcomas arising in the irradiation field of a primary tumour following radiotherapy. The allelic status and the presence of mutations of the TP53 gene were investigated. The mutation pattern was compared with data...
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