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Article

Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.

European journal of endocrinology - 1 Jun 1999

Poncin J, Stevenaert A, Beckers A

Abstract excerpt

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in these sporadic tumours. The MEN1 gene located on 11q13 has recently been cloned and allelic deletion and mutation analysis studies have implicated the MEN1 gene in a significant fraction of the sporadic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10366412
DOI: 10.1530/eje.0.1400573

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.PMID 10366412Read ↗

Analysis of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

Mutations of the MEN1 tumor suppressor gene in sporadic pituitary tumors.Semantic proximity Read ↗

Molecular Characterization of the Men1 Tumor Suppressor Gene in Sporadic Pituitary TumorsSemantic proximity Read ↗

Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors.Semantic proximity Read ↗

Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.Semantic proximity Read ↗

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.Semantic proximity Read ↗

MEN1 gene analysis in sporadic adrenocortical neoplasms.Semantic proximity Read ↗

Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors.Semantic proximity Read ↗

The MEN-1 gene is rarely down-regulated in pituitary adenomas.Semantic proximity Read ↗

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.Semantic proximity Read ↗

Lack of MEN1 gene mutations in 27 sporadic insulinomas.Semantic proximity Read ↗

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