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Article

Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors.

Journal of endocrinological investigation - 1 May 2000

Evans C O, Brown M R, Parks J S, Oyesiku N M

Abstract excerpt

The molecular pathogenesis of the majority of sporadic pituitary tumors is largely unknown. Pituitary adenomas can develop sporadically or as a part of multiple endocrine neoplasia type 1 (MEN1). The MEN1 is thought to be a tumor suppressor gene based on loss of heterozygosity (LOH) for polymorphic markers on 11q13 in tumors of the pancreas, parathyroid, and pituitary. Most patients with familial and sporadic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

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Share to Multiple Endocrine Neoplasia Type 1

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Source

Identifiers

PMID: 10882148
DOI: 10.1007/BF03343727

Genes

MEN1
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors.PMID 10882148Read ↗

Analysis of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.Semantic proximity Read ↗

Mutations of the MEN1 tumor suppressor gene in sporadic pituitary tumors.Semantic proximity Read ↗

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

Alterations of the MEN1 gene in sporadic parathyroid tumors.Semantic proximity Read ↗

Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.Semantic proximity Read ↗

11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.Semantic proximity Read ↗

Molecular Characterization of the Men1 Tumor Suppressor Gene in Sporadic Pituitary TumorsSemantic proximity Read ↗

Screening of the Men1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors.Semantic proximity Read ↗

Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.Semantic proximity Read ↗

The MEN-1 gene is rarely down-regulated in pituitary adenomas.Semantic proximity Read ↗

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.Semantic proximity Read ↗

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