Article
The MEN-1 gene is rarely down-regulated in pituitary adenomas.
The Journal of clinical endocrinology and metabolism - 1 Sept 1998
Asa S L, Somers K, Ezzat S
Abstract excerpt
The gene for multiple endocrine neoplasia type 1 (MEN-1) has recently been cloned and encodes a putative tumor suppressor protein named menin. We have previously reported inactivating MEN-1 gene mutations associated with loss of heterozygosity (LOH) of the normal allele in tumors of patients with...
Topics
- Adenoma
- Adult
- Aged
- DNA, Neoplasm
- Female
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Neoplasm Proteins
- Pituitary Neoplasms
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- RNA, Messenger