Article
The MEN-1 gene is rarely down-regulated in pituitary adenomas.
The Journal of clinical endocrinology and metabolism - 1 Sept 1998
Asa S L, Somers K, Ezzat S
Abstract excerpt
The gene for multiple endocrine neoplasia type 1 (MEN-1) has recently been cloned and encodes a putative tumor suppressor protein named menin. We have previously reported inactivating MEN-1 gene mutations associated with loss of heterozygosity (LOH) of the normal allele in tumors of patients with MEN-1 and in some sporadic pituitary tumors. These genetic alterations, however, are noted in no more than 10% of...
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