Article
Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
Cancer research - 15 Dec 1997
Zhuang Z, Ezzat S Z, Vortmeyer A O, Weil R, Oldfield E H, Park W S, Pack S, Huang S, Agarwal S K, Guru S C, Manickam P, Debelenko L V, Kester M B, Olufemi S E, Heppner C, Crabtree J S, Burns A L, Spiegel A M, Marx S J, Chandrasekharappa S C, Collins F S, Emmert-Buck M R, Liotta L A, Asa S L, Lubensky I A
Abstract excerpt
Although pituitary adenomas are monoclonal proliferations, somatic mutations involving genes that govern cell proliferation or hormone production have been difficult to identify. The genetic etiology of most pituitary tumors, therefore, remains unknown. Pituitary adenomas can develop sporadically or as a part of multiple endocrine neoplasia type 1 (MEN1). Recently, the gene responsible for MEN1 was cloned. To...
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