Article
Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jul 2001
Costa S C, Nascimento L S, Ferreira F J, Mattos P S, Camara-Lopes L H, Ward L S
Abstract excerpt
In addition to the mutations that underlie most cases of the multiple endocrine neoplasia type 1 (MEN1) syndrome, somatic mutations of the MEN1 gene have also been described in sporadic tumors like gastrinomas, insulinomas and bronchial carcinoid neoplasm. We examined exon 2 of this gene, where most of the mutations have been described, in 148 endocrine and nonendocrine sporadic tumors. DNA was obtained by...
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