Article
Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.
The Journal of clinical endocrinology and metabolism - 1 Apr 1998
Prezant T R, Levine J, Melmed S
Abstract excerpt
Anterior pituitary tumors arise sporadically, and also as part of the inherited multiple endocrine neoplasia type 1 (MEN 1) syndrome. To investigate the role of the recently isolated men1 gene in sporadic pituitary tumorigenesis, the complete coding sequence was screened for mutations in 45 sporadic anterior pituitary tumors, including 14 hormone-secreting tumors and 31 nonsecreting tumors, by dideoxy...
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