Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.

doi:10.1210/jcem.83.4.4859

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Article

Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.

The Journal of clinical endocrinology and metabolism - 1 Apr 1998

Prezant T R, Levine J, Melmed S

Abstract excerpt

Anterior pituitary tumors arise sporadically, and also as part of the inherited multiple endocrine neoplasia type 1 (MEN 1) syndrome. To investigate the role of the recently isolated men1 gene in sporadic pituitary tumorigenesis, the complete coding sequence was screened for mutations in 45 spora...

Topics

Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genetic Testing
Humans
Loss of Heterozygosity
Multiple Endocrine Neoplasia Type 1
Mutation
Periodicity
Pituitary Neoplasms

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