Analysis of the MEN1 gene in sporadic pituitary adenomas.

doi:10.1002/(SICI)1096-9896(199906)188:2<168::AID-PATH342>3.0.CO;2-4

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Article

Analysis of the MEN1 gene in sporadic pituitary adenomas.

The Journal of pathology - 1 Jun 1999

Schmidt M C, Henke R T, Stangl A P, Meyer-Puttlitz B, Stoffel-Wagner B, Schramm J, von Deimling A

Abstract excerpt

The MEN1 gene on chromosome 11q13 is mutated in patients afflicted with multiple endocrine neoplasia syndrome type 1 (MEN1). These patients develop endocrine tumours of the pancreas, the parathyroid, and the anterior pituitary. In order to determine the role of MEN1 in sporadic pituitary adenomas, 61 pituitary adenomas were analysed from patients without evidence of a familial tumour syndrome. Single strand...

Topics

Adenoma
Chromosomes, Human, Pair 11
DNA Primers
Gene Deletion
Humans
Loss of Heterozygosity
Multiple Endocrine Neoplasia
Mutation
Pituitary Neoplasms
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 10398160
DOI: 10.1002/(SICI)1096-9896(199906)188:2<168::AID-PATH342>3.0.CO;2-4

Genes

MEN1

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