Article
Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand.
Clinical and experimental immunology - 1 Jun 1999
Huang S C, Glas A M, Pinchuk G V, Van Montfort E H, Rao S P, Jiang R, Milner E C
Abstract excerpt
The acquisition of somatic mutations in the rearranged immunoglobulin V regions in B cells occurs within the tightly regulated microenvironment of a germinal centre. The precise mechanism responsible for turning on the mutational process is unknown. To dissect the role of different components of the germinal centre in this mechanism, we have used in vitro cultures of normal human IgD+ peripheral blood B...
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