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Article

Somatic mutation. From the dark zone to the light.

Current biology : CB - 1 Jan 1994

MacLennan I C

Abstract excerpt

The affinity maturation of antibodies that occurs during immune responses to protein antigens involves site-directed hypermutation of immunoglobulin variable-region genes that is activated in germinal centres.

Read the complete abstract on PubMed

Topics

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Share to Antigens
Share to B-Lymphocytes
Share to Genes, Immunoglobulin
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Spleen

Share to T-Lymphocytes

Share to Immunoglobulin Variable Region

Share to Models, Biological

Source

Identifiers

PMID: 7922318
DOI: 10.1016/s0960-9822(00)00017-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of AntibodiesSemantic proximity Read ↗

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