Somatic mutation. From the dark zone to the light.

doi:10.1016/s0960-9822(00)00017-8

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Article

Somatic mutation. From the dark zone to the light.

Current biology : CB - 1 Jan 1994

MacLennan I C

Abstract excerpt

The affinity maturation of antibodies that occurs during immune responses to protein antigens involves site-directed hypermutation of immunoglobulin variable-region genes that is activated in germinal centres.

Topics

Animals
Antibody Formation
Antigens
B-Lymphocytes
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Models, Biological
Mutation
Spleen
T-Lymphocytes

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