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Article

Signals sustaining human immunoglobulin V gene hypermutation in isolated germinal centre B cells.

Immunology - 1 Oct 2000

Dahlenborg K, Pound J D, Gordon J, Borrebaeck C A, Carlsson R

Abstract excerpt

Affinity maturation of antibody responses depends on somatic hypermutation of the immunoglobulin V genes. Hypermutation is initiated specifically in proliferating B cells in lymphoid germinal centres but the signals driving this process remain unknown. This study identifies signals that promote V gene mutation in human germinal centre (GC) B cells in vitro. Single GC B cells were cultured by limiting dilution to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11012774
DOI: 10.1046/j.1365-2567.2000.00091.x
PMCID: PMC2327070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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