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Article

Intraclonal generation of antibody mutants in germinal centres.

Nature - 5 Dec 1991

Jacob J, Kelsoe G, Rajewsky K, Weiss U

Abstract excerpt

The generation and selection of somatic antibody mutants are key elements of acquired immunity, essential for the affinity maturation of antibody responses dependent on T cells. The mutants are generated through a mechanism that introduces point mutations at high rate into rearranged variable (V) region genes in the course of cell proliferation. Their appearance coincides with the generation of germinal centres,...

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PMID: 1956400
DOI: 10.1038/354389a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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