Article
Intraclonal generation of antibody mutants in germinal centres.
Nature - 5 Dec 1991
Jacob J, Kelsoe G, Rajewsky K, Weiss U
Abstract excerpt
The generation and selection of somatic antibody mutants are key elements of acquired immunity, essential for the affinity maturation of antibody responses dependent on T cells. The mutants are generated through a mechanism that introduces point mutations at high rate into rearranged variable (V)...
Topics
- Amino Acid Sequence
- Animals
- Antibody Affinity
- B-Lymphocytes
- Base Sequence
- Clone Cells
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Immunoglobulin Variable Region
- Lymphoid Tissue
- Mice
- Molecular Sequence Data
- Mutation
- Nitrophenols
- Phenylacetates