Article
Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts.
Immunity - 1 Jun 1996
Liu Y J, de Bouteiller O, Arpin C, Brière F, Galibert L, Ho S, Martinez-Valdez H, Banchereau J, Lebecque S
Abstract excerpt
Somatic hypermutation in immunoglobulin variable region genes occurs within germinal centers. Here, we describe a subset of germinal center dark zone centroblasts that express only sIgD and have accumulated up to 80 mutations per heavy chain variable region (IgVH delta gene). Over half of the hyp...
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Antigens, CD
- Antigens, Differentiation
- B-Lymphocytes
- Base Sequence
- Biomarkers
- Cell Cycle
- Cell Differentiation
- Clone Cells
- Germinal Center
- Humans
- Immunoglobulin D
- Immunoglobulin Heavy Chains
- Immunoglobulin M