Article
Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.
Nature - 9 Nov 2000
Papavasiliou F N, Schatz D G
Abstract excerpt
Targeted hypermutation of immunoglobulin variable region genes occurs in B cells during an immune response, and gives rise to families of related mutant antibodies which are then selected for their binding affinity to the immunizing antigen. Somatic hypermutation predominantly generates point mutations, many of which occur at specific residues (hotspots). The reaction has been linked to transcription and requires...
Topics
- Animals
- Cell Cycle
- Cell Line
- Cloning, Molecular
- DNA
- DNA Damage
- DNA Repair
- Enhancer Elements, Genetic
- Genes, Immunoglobulin
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred C57BL