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Article

Somatic mutation of immunoglobulin V genes in vitro.

Science (New York, N.Y.) - 1 Mar 1996

Källberg E, Jainandunsing S, Gray D, Leanderson T

Abstract excerpt

The molecular mechanism behind affinity maturation is the introduction of point mutations in immunoglobulin (Ig) V genes, followed by the selective proliferation of B cells expressing mutants with increased affinity for antigen. An in vitro culture system was developed in which somatic hypermutation of Ig V genes was sustained in primed B cells. Cognate T cell help and cross-linking of the surface Ig were...

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Identifiers

PMID: 8638111
DOI: 10.1126/science.271.5253.1285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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