Article
Acceleration of the refolding of Arc repressor by nucleic acids and other polyanions.
Nature structural biology - 1 Jun 1999
Rentzeperis D, Jonsson T, Sauer R T
Abstract excerpt
The refolding rate of the Arc repressor dimer can be accelerated 30-fold or more by negatively charged polymers including single-stranded and double-stranded DNA, RNA, and polyvinylsulfate but not by neutral or positively charged polymers. The salt-dependence of the polyanion-mediated process and mutant studies indicate that electrostatic interactions are important in the rate acceleration. Urea-dependence...
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