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Article

The solution structure and dynamics of an Arc repressor mutant reveal premelting conformational changes related to DNA binding.

Biochemistry - 11 May 1999

Nooren I M, Rietveld A W, Melacini G, Sauer R T, Kaptein R, Boelens R

Abstract excerpt

The solution structure of the hyperstable MYL mutant (R31M/E36Y/R40L) of the Arc repressor of bacteriophage P22 was determined by NMR spectroscopy and compared to that of the wild-type Arc repressor. A backbone rmsd versus the average of 0.37 A was obtained for the well-defined core region. For both Arc-MYL and the wild-type Arc repressor, evidence for a fast equilibrium between a packed ("in") conformation and...

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Identifiers

PMID: 10320329
DOI: 10.1021/bi982677t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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