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Article

Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction.

Nature structural biology - 1 Jun 1999

Walter N G, Burke J M, Millar D P

Abstract excerpt

The equilibrium distributions of hairpin ribozyme conformational isomers have been examined by time-resolved fluorescence resonance energy transfer. Ribozymes partition between active (docked) and inactive (extended) conformers, characterized by unique interdomain distance distributions, which define differences in folding free energy. The active tertiary structure is stabilized both by specific interactions...

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PMID: 10360357
DOI: 10.1038/9316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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