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Article

Dynamics differentiate between active and inactive inteins.

European journal of medicinal chemistry - 16 Feb 2015

Cronin Melissa, Coolbaugh Michael J, Nellis David, Zhu Jianwei, Wood David W, Nussinov Ruth, Ma Buyong

Abstract excerpt

The balance between stability and dynamics for active enzymes can be somewhat quantified by studies of intein splicing and cleaving reactions. Inteins catalyze the ligation of flanking host exteins while excising themselves. The potential for applications led to engineering of a mini-intein splicing domain, where the homing endonuclease domain of the Mycobacterium tuberculosis RecA (Mtu recA) intein was removed....

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Source

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Identifiers

PMID: 25087201
DOI: 10.1016/j.ejmech.2014.07.094
PMCID: PMC4308580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamics differentiate between active and inactive inteins.PMID 25087201Read ↗

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V67L Mutation Fills an Internal Cavity To Stabilize RecA Mtu Intein.Semantic proximity Read ↗

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