Article
Self-association of adenine-dependent hairpin ribozymes.
European biophysics journal : EBJ - 1 Feb 2008
Li Yan-Li, Maurel Marie-Christine, Ebel Christine, Vergne Jacques, Pipich Vitaliy, Zaccai Giuseppe
Abstract excerpt
Hairpin ribozymes are flexible molecules that catalyse reversible self-cleavage after the docking of two independently folded internal loops, A and B. The activities, self-association and structures in solution of two 85 base adenine-dependent hairpin ribozymes (ADHR1 and ADHR2) were studied by native gel electrophoresis, analytical centrifugation, and small angle neutron scattering. Bi-molecular RNA interactions...
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