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Article

Tertiary interactions determine the accuracy of RNA folding.

Journal of the American Chemical Society - 30 Jan 2008

Chauhan Seema, Woodson Sarah A

Abstract excerpt

RNAs must fold into unique three-dimensional structures to function in the cell, but how each polynucleotide finds its native structure is not understood. To investigate whether the stability of the tertiary structure determines the speed and accuracy of RNA folding, docking of a tetraloop with its receptor in a bacterial group I ribozyme was perturbed by site-directed mutagenesis. Disruption of the tetraloop or...

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Identifiers

PMID: 18179212
DOI: 10.1021/ja076166i
PMCID: PMC2526051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tertiary interactions determine the accuracy of RNA folding.PMID 18179212Read ↗

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Perturbation of the hierarchical folding of a large RNA by the destabilization of its Scaffold's tertiary structure.Semantic proximity Read ↗

Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

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Kinetic intermediates trapped by native interactions in RNA folding.Semantic proximity Read ↗

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