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Article

The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.

PloS one - 1 Jan 2012

Trierweiler Claudia, Blum Hubert E, Hasselblatt Peter

Abstract excerpt

BACKGROUND: The Wnt/β-Catenin signaling pathway is central for liver functions and frequently deregulated in hepatocellular carcinoma (HCC). Analysis of the early phenotypes and molecular events following β-Catenin activation is therefore essential for better understanding HCC pathogenesis. The AP-1 transcription factor c-Jun is a putative β-Catenin target gene and promotes hepatocyte survival, proliferation, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22792392
DOI: 10.1371/journal.pone.0040638
PMCID: PMC3391288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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