Article
Jun is required in Isl1-expressing progenitor cells for cardiovascular development.
PloS one - 1 Jan 2013
Zhang Tao, Liu Junchen, Zhang Jue, Thekkethottiyil Eldhose B, Macatee Timothy L, Ismat Fraz A, Wang Fen, Stoller Jason Z
Abstract excerpt
Jun is a highly conserved member of the multimeric activator protein 1 transcription factor complex and plays an important role in human cancer where it is known to be critical for proliferation, cell cycle regulation, differentiation, and cell death. All of these biological functions are also crucial for embryonic development. Although all Jun null mouse embryos die at mid-gestation with persistent truncus...
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