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Article

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.

Nature - 25 May 1995

Perkins A C, Sharpe A H, Orkin S H

Abstract excerpt

Globin genes are regulated in a tissue-specific and developmental stage-specific manner, with the beta-globin gene being the last to be activated in the beta-gene cluster. CACCC-nucleotide sequences, which bind multiple nuclear proteins, including ubiquitously expressed Sp1 and erythroid Krüppel-like factor (EKLF), are among the cis-regulatory sequences critical for transcription of globin and non-globin...

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PMID: 7753195
DOI: 10.1038/375318a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Click a neighbor to travelStep 1 · 12 closest

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.PMID 7753195Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)Semantic proximity Read ↗

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingSemantic proximity Read ↗

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Semantic proximity Read ↗

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.Semantic proximity Read ↗

Krüppel-Like Factor 1: A Pivotal Gene Regulator in ErythropoiesisSemantic proximity Read ↗

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.Semantic proximity Read ↗

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression.Semantic proximity Read ↗

Loss of LKLF function results in embryonic lethality in mice.Semantic proximity Read ↗

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.Semantic proximity Read ↗

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoSemantic proximity Read ↗

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.Semantic proximity Read ↗

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