Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.

doi:10.1038/375318a0

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Article

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.

Nature - 25 May 1995

Perkins A C, Sharpe A H, Orkin S H

Abstract excerpt

Globin genes are regulated in a tissue-specific and developmental stage-specific manner, with the beta-globin gene being the last to be activated in the beta-gene cluster. CACCC-nucleotide sequences, which bind multiple nuclear proteins, including ubiquitously expressed Sp1 and erythroid Krüppel-...

Topics

Anemia
Animals
Base Sequence
Cell Line
DNA
DNA-Binding Proteins
Egg Yolk
Erythropoiesis
Female
Fetal Death
Gene Targeting
Genes, Switch
Globins
Kruppel-Like Transcription Factors
Liver
Male
Mice
Mice, Inbred BALB C

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