Article

Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifs

2020-08-11

Abstract excerpt

<h4>ABSTRACT</h4> XRN1 is a highly conserved exoribonuclease which degrades uncapped RNAs in a 5’-3’ direction. Degradation of RNAs by XRN1 is important in many cellular and developmental processes and is relevant to human disease. Studies in D. melanogaster demonstrate that XRN1 can target specific RNAs, which have important consequences for developmental pathways. Osteosarcoma is a malignancy of the bone and a...

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Literature Corpus work: e93e0996-e6f2-524c-92f3-3b69b1bd8caa
DOI: 10.1101/2020.08.11.246249

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