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Article

Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively.

Molecular and cellular biology - 1 Oct 1997

Johnson A W

Abstract excerpt

XRN1 encodes an abundant cytoplasmic exoribonuclease, Xrn1p, responsible for mRNA turnover in yeast. A screen for bypass suppressors of the inviability of xrn1 ski2 double mutants identified dominant alleles of RAT1, encoding an exoribonuclease homologous with Xrn1p. These RAT1 alleles restored XRN1-like functions, including cytoplasmic RNA turnover, wild-type sensitivity to the microtubule-destabilizing drug...

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Identifiers

PMID: 9315672
DOI: 10.1128/MCB.17.10.6122
PMCID: PMC232462

Genes

XRN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively.PMID 9315672Read ↗

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Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae.Semantic proximity Read ↗

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Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.Semantic proximity Read ↗

Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.Semantic proximity Read ↗

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.Semantic proximity Read ↗

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Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis.Semantic proximity Read ↗

Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1.Semantic proximity Read ↗

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The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

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