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The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs.

Cell reports - 17 Oct 2017

Gerstberger Stefanie, Meyer Cindy, Benjamin-Hong Sigi, Rodriguez Joe, Briskin Daniel, Bognanni Claudia, Bogardus Kimberly, Steller Hermann, Tuschl Thomas

Abstract excerpt

Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3'-5' single-stranded RNA exonucleases, by genetic, biochemical, and RNA-sequencing approaches. Rexo5 is required for small nucleolar RNA (snoRNA) and rRNA biogenesis and is essential in D. melanogaster. Loss-of-function...

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Identifiers

PMID: 29045842
DOI: 10.1016/j.celrep.2017.09.067
PMCID: PMC5662206

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