Article
Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.
PloS one - 1 Jan 2025
Jordán-Pla Antonio, Zhang Yujie, García-Martínez José, Chattopadhyay Shiladitya, Forte Anabel, Choder Mordechai, Pelechano Vicent, Pérez-Ortín José E
Abstract excerpt
The budding yeast Xrn1 protein shuttles between the nucleus, where it stimulates transcription, and the cytoplasm, where it executes the major cytoplasmic mRNA decay. In the cytoplasm, apart from catalyzing 5'→3' decay onto non translated mRNAs, Xrn1 can follow the last translating ribosome to degrade the decapped mRNA template, a process known as "cotranslational mRNA decay". We have previously observed that the...
Read the complete abstract on PubMedTopics
- Exoribonucleases
- RNA Stability
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Cell Nucleus
- RNA, Messenger