Article
Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae.
Nucleic acids research - 15 Aug 1998
Page A M, Davis K, Molineux C, Kolodner R D, Johnson A W
Abstract excerpt
Exoribonuclease I from yeast is a 175 kDa protein that is responsible for the majority of cytoplasmic mRNA degradation. Alignment of the Xrn1p sequence with homologs from yeast as well as from higher eukaryotes suggests that the protein is composed of several domains: two acidic N-terminal domains which likely contain the exonuclease, a basic middle domainand a basic C-terminal domain. Deletion...
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