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Article

Mouse patched1 controls body size determination and limb patterning.

Development (Cambridge, England) - 1 Oct 1999

Milenkovic L, Goodrich L V, Higgins K M, Scott M P

Abstract excerpt

Hedgehog (Hh) proteins control many developmental events by inducing specific cell fates or regulating cell proliferation. The Patched1 (Ptc1) protein, a binding protein for Hh molecules, appears to oppose Hh signals by repressing transcription of genes that can be activated by Hh. Sonic hedgehog (Shh), one of the vertebrate homologs of Hh, controls patterning and growth of the limb but the early embryonic...

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Identifiers

PMID: 10498679
DOI: 10.1242/dev.126.20.4431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse patched1 controls body size determination and limb patterning.PMID 10498679Read ↗

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