Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.

Genetics - 1 Jan 2009

Cooper Katrina F, Mallory Michael J, Guacci Vincent, Lowe Katherine, Strich Randy

Abstract excerpt

Sister-chromatid separation at the metaphase-anaphase transition is regulated by a proteolytic cascade. Destruction of the securin Pds1p liberates the Esp1p separase, which ultimately targets the mitotic cohesin Mcd1p/Scc1p for destruction. Pds1p stabilization by the spindle or DNA damage checkpoints prevents sister-chromatid separation while mutants lacking PDS1 (pds1Delta) are temperature sensitive for growth...

Topics

Cell Cycle Proteins
Chromatin
Chromosomal Proteins, Non-Histone
DNA Breaks, Double-Stranded
Gene Deletion
Gene Expression Regulation, Fungal
Genes, Fungal
Meiotic Prophase I
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

Recombination, Genetic

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Securin

Signal Transduction

Spindle Apparatus

Synaptonemal Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 19001291
DOI: 10.1534/genetics.108.095513
PMCID: PMC2621190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.PMID 19001291Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).Semantic proximity Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae cells lacking the homologous pairing protein p175SEP1 arrest at pachytene during meiotic prophase.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.Semantic proximity Read ↗

Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.Semantic proximity Read ↗

The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.Semantic proximity Read ↗

The Saccharomyces cerevisiae PDS1 and RAD9 checkpoint genes control different DNA double-strand break repair pathways.Semantic proximity Read ↗

Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.