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Article

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.

Genetics - 1 Jan 2009

Cooper Katrina F, Mallory Michael J, Guacci Vincent, Lowe Katherine, Strich Randy

Abstract excerpt

Sister-chromatid separation at the metaphase-anaphase transition is regulated by a proteolytic cascade. Destruction of the securin Pds1p liberates the Esp1p separase, which ultimately targets the mitotic cohesin Mcd1p/Scc1p for destruction. Pds1p stabilization by the spindle or DNA damage checkpoints prevents sister-chromatid separation while mutants lacking PDS1 (pds1Delta) are temperature sensitive for growth...

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Source

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Identifiers

PMID: 19001291
DOI: 10.1534/genetics.108.095513
PMCID: PMC2621190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.PMID 19001291Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).Semantic proximity Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae cells lacking the homologous pairing protein p175SEP1 arrest at pachytene during meiotic prophase.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.Semantic proximity Read ↗

Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.Semantic proximity Read ↗

The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.Semantic proximity Read ↗

The Saccharomyces cerevisiae PDS1 and RAD9 checkpoint genes control different DNA double-strand break repair pathways.Semantic proximity Read ↗

Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint.Semantic proximity Read ↗

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