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Article

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.

Genes & development - 1 Nov 1998

Furuya K, Takahashi K, Yanagida M

Abstract excerpt

The loss of sister chromatid cohesion triggers anaphase spindle movement. The budding yeast Mcd1/Scc1 protein, called cohesin, is required for associating chromatids, and proteins homologous to it exist in a variety of eukaryotes. Mcd1/Scc1 is removed from chromosomes in anaphase and degrades in G1. We show that the fission yeast protein, Mis4, which is required for equal sister chromatid separation in anaphase...

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Identifiers

PMID: 9808627
DOI: 10.1101/gad.12.21.3408
PMCID: PMC317234

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