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Article

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

Genes & development - 15 Mar 1994

Weinert T A, Kiser G L, Hartwell L H

Abstract excerpt

In eukaryotes a cell-cycle control termed a checkpoint causes arrest in the S or G2 phases when chromosomes are incompletely replicated or damaged. Previously, we showed in budding yeast that RAD9 and RAD17 are checkpoint genes required for arrest in the G2 phase after DNA damage. Here, we describe a genetic strategy that identified four additional checkpoint genes that act in two pathways. Both classes of genes...

Topics

Alleles
Cell Cycle
Cell Cycle Proteins
Chromosome Mapping
Crosses, Genetic
DNA Repair
DNA Replication
Fungal Proteins
Genes, Fungal
Genes, Lethal
Genes, Synthetic
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxyurea

Mitosis

Saccharomyces cerevisiae

Source

Identifiers

PMID: 7926756
DOI: 10.1101/gad.8.6.652

Genes

RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7926756-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.PMID 7926756Read ↗

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