Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.

Genes & development - 1 Jun 2001

Wang H, Liu D, Wang Y, Qin J, Elledge S J

Abstract excerpt

In Saccharomyces cerevisiae, Pds1 is an anaphase inhibitor and plays an essential role in DNA damage and spindle checkpoint pathways. Pds1 is phosphorylated in response to DNA damage but not spindle disruption, indicating distinct mechanisms delaying anaphase entry. Phosphorylation of Pds1 is Mec1 and Chk1 dependent in vivo. Here, we show that Pds1 is phosphorylated at multiple sites in vivo in response to DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cdc20 Proteins
Share to Cell Cycle Proteins
Share to Checkpoint Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Electrophoresis, Polyacrylamide Gel

Share to Genes, cdc

Share to Protein Kinases

Share to Securin

Source

Open in PubMed Open full text

Identifiers

PMID: 11390356
DOI: 10.1101/gad.893201
PMCID: PMC312708

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.PMID 11390356Read ↗

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.Semantic proximity Read ↗

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1Semantic proximity Read ↗

Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.Semantic proximity Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency.Semantic proximity Read ↗

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.Semantic proximity Read ↗

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.