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Article

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

The Journal of cell biology - 1 Apr 1996

Yamamoto A, Guacci V, Koshland D

Abstract excerpt

We report the isolation and characterization of pds1 mutants in Saccharomyces cerevisiae. The initial pds1-1 allele was identified by its inviability after transient exposure to microtubule inhibitors and its precocious dissociation of sister chromatids in the presence of these microtubule inhibitors. These findings suggest that pds1 mutants might be defective in anaphase arrest that normally is imposed by a...

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Identifiers

PMID: 8601617
DOI: 10.1083/jcb.133.1.99
PMCID: PMC2120772

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).PMID 8601617Read ↗

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Semantic proximity Read ↗

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase.Semantic proximity Read ↗

Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control.Semantic proximity Read ↗

Dominant alleles of Saccharomyces cerevisiae CDC20 reveal its role in promoting anaphase.Semantic proximity Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae.Semantic proximity Read ↗

Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit.Semantic proximity Read ↗

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