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Article

G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.

Molecular and cellular biology - 1 Dec 2012

Manfrini Nicola, Gobbini Elisa, Baldo Veronica, Trovesi Camilla, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

The Mec1 and Rad53 protein kinases are essential for budding yeast cell viability and are also required to activate the S-phase checkpoint, which supports DNA replication under stress conditions. Whether these two functions are related to each other remains to be determined, and the nature of the replication stress-dependent lethality of mec1 and rad53 mutants is still unclear. We show here that a decrease in...

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Identifiers

PMID: 23045388
DOI: 10.1128/MCB.00956-12
PMCID: PMC3510536

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G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.PMID 23045388Read ↗

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