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Article

Evidence for dimerization of dimers in K+ channel assembly.

Biophysical journal - 1 Apr 1999

Tu L, Deutsch C

Abstract excerpt

Voltage-gated K+ channels are tetrameric, but how the four subunits assemble is not known. We analyzed inactivation kinetics and peak current levels elicited for a variety of wild-type and mutant Kv1.3 subunits, expressed singly, in combination, and as tandem constructs, to show that 1) the dominant pathway involves a dimerization of dimers, and 2) dimer-dimer interaction may involve interaction sites that differ...

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Identifiers

PMID: 10096897
DOI: 10.1016/S0006-3495(99)77358-3
PMCID: PMC1300175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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