Article
Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
The Journal of biological chemistry - 7 Nov 2008
Bal Manjot, Zhang Jie, Zaika Oleg, Hernandez Ciria C, Shapiro Mark S
Abstract excerpt
M-type K(+) channels, consisting of KCNQ1-5 (Kv7.1-7.5) subunits, form a variety of homomeric and heteromeric channels. Whereas all the subunits can assemble into homomeric channels, the ability of the subunits to assemble into heteromultimers is highly variable. KCNQ3 is widely thought to co-ass...
Topics
- Animals
- CHO Cells
- Cricetinae
- Cricetulus
- Fluorescence Resonance Energy Transfer
- Gene Expression
- Humans
- KCNQ Potassium Channels
- Mutation
- Patch-Clamp Techniques
- Protein Structure, Quaternary
- Rats