Both N- and C-terminal regions contribute to the assembly and functional expression of homo- and heteromultimeric voltage-gated K+ channels.

Abstract excerpt

The functional diversity of voltage-gated K+ channels may be partially determined by the mechanisms that permit or limit the assembly of molecularly diverse K+ channel subunits. To determine possible amino acid sequence domains required for subunit assembly and expression, we have constructed 15 N- and C-terminal interstitial or truncation deletion mutations in mKv1.1 (MBK1), a mouse Shaker-like K+ channel. We...

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