Article
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
Japanese journal of cancer research : Gann - 1 Dec 2001
Gen H, Yamamoto S, Morimura K, Min W, Mitsuhashi M, Murai T, Mori S, Hosono M, Oohara T, Makino S, Wanibuchi H, Fukushima S
Abstract excerpt
We previously reported p53 mutations to be frequent (greater than 70%), whereas both H-ras mutations and microsatellite instability (MSI) were infrequent (about 10%), in urinary bladder carcinomas (UBCs) and their metastatic foci in the N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced mouse urothelial carcinogenesis model. In the present study, an analysis of p53 and H-ras mutations as well as MSI was...
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