Article
Possible rare involvement of O6-methylguanine formation as a significant mutational factor in mouse urinary bladder carcinogenesis models.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1998
Chen T, Yamamoto S, Kitano M, Murai T, Wanibuchi H, Matsukuma S, Nakatsuru Y, Ishikawa T, Fukushima S
Abstract excerpt
O6-methylguanine is known as one of the major premutagenic lesions in the human and rodent carcinogenesis process. O6-methylguanine-DNA methyltransferase (MGMT), which repairs methylated guanine bases, might prevent the G:C to A:T transition, and transgenic mice carrying this MGMT gene have been reported to be less sensitive to the carcinogenicity of certain alkylating agents. Here we utilized MGMT transgenic...
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