Article
Possible rare involvement of O6-methylguanine formation as a significant mutational factor in mouse urinary bladder carcinogenesis models.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1998
Chen T, Yamamoto S, Kitano M, Murai T, Wanibuchi H, Matsukuma S, Nakatsuru Y, Ishikawa T, Fukushima S
Abstract excerpt
O6-methylguanine is known as one of the major premutagenic lesions in the human and rodent carcinogenesis process. O6-methylguanine-DNA methyltransferase (MGMT), which repairs methylated guanine bases, might prevent the G:C to A:T transition, and transgenic mice carrying this MGMT gene have been...
Topics
- Adenosine Deaminase
- Animals
- Butylhydroxybutylnitrosamine
- Carcinogens
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Epithelium
- Female
- Genes, p53
- Guanine
- Humans
- Incidence
- Male
- Mice
- Mice, Inbred C3H