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Article

Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.

Mutation research - 2 Jun 2001

Fukushima S

Abstract excerpt

The significance of O6-methylguanine formation in urinary bladder carcinogenesis was examined using O6-methylguanine-DNA methyltransferase (MGMT) transgenic mice carrying the ada gene. The ada MGMT transgenic mice demonstrated no differences in development of carcinogens-induced urinary bladder carcinomas compared with non-transgenic mice. Furthermore, no variation in p53 mutation frequency was evident between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylnitrosourea

Share to Mice, Inbred C3H

Share to O(6)-Methylguanine-DNA Methyltransferase

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 11376694
DOI: 10.1016/s0027-5107(01)00114-2

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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