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Biology of urothelial tumorigenesis: insights from genetically engineered mice

1 Dec 2009

Abstract excerpt

Urothelium, one of the slowest cycling epithelia in the body, embodies a unique biological context for cellular transformation. Introduction of oncogenes into or removing tumor suppressor genes from the urothelial cells or a combination of both using the transgenic and/or knockout mouse approaches has provided useful insights into the molecular mechanisms of urothelial transformation and tumorigenesis. It is...

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PMID: 20012171
DOI: 10.1007/s10555-009-9189-4

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