Article
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1999
Phung Q H, Winter D B, Alrefai R, Gearhart P J
Abstract excerpt
During somatic hypermutation of Ig V genes, mismatched nucleotide substitutions become candidates for removal by the DNA mismatch repair pathway. Previous studies have shown that V genes from mice deficient for the MSH2 and PMS2 mismatch repair proteins have frequencies of mutation that are comparable with those from wild-type (wt) mice; however, the pattern of mutation is altered. Because the absence of MSH2 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.