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Article

Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis.

DNA repair - 7 Oct 2003

Takagi Yasumitsu, Takahashi Masayuki, Sanada Masayuki, Ito Riyoko, Yamaizumi Masaru, Sekiguchi Mutsuo

Abstract excerpt

To examine involvement of mismatch repair system in alkylation-induced apoptosis and mutagenesis, cell lines defective in the Mgmt gene encoding a DNA repair enzyme, O(6)-methylguanine-DNA methyltransferase, and/or the Mlh1 gene encoding a protein involved in mismatch repair were established from gene-targeted mice. Mgmt(-/-) cells are hypersensitive to the killing effect of N-methyl-N-nitrosourea (MNU) and this...

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Source

Identifiers

PMID: 13679151
DOI: 10.1016/s1568-7864(03)00134-4

Genes

MLH1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis.PMID 13679151Read ↗

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