Article

Cutting Edge: Hypermutation in Ig V Genes from Mice Deficient in the MLH1 Mismatch Repair Protein

1999-03-01

Abstract excerpt

Abstract During somatic hypermutation of Ig V genes, mismatched nucleotide substitutions become candidates for removal by the DNA mismatch repair pathway. Previous studies have shown that V genes from mice deficient for the MSH2 and PMS2 mismatch repair proteins have frequencies of mutation that are comparable with those from wild-type (wt) mice; however, the pattern of mutation is altered. Because the absence of...

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Literature Corpus work: 7089b8a8-f7c5-5ea0-9a1a-ad100d8cb74c
DOI: 10.4049/jimmunol.162.6.3121

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