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Article

High Mutation Levels are Compatible with Normal Embryonic Development in Mlh1-Deficient Mice.

Radiation research - 1 Oct 2016

Fan Xiaoyan, Li Yan, Zhang Yulong, Sang Meixiang, Cai Jianhui, Li Qiaoxia, Ozaki Toshinori, Ono Tetsuya, He Dongwei

Abstract excerpt

To elucidate the role of the mismatch repair gene Mlh1 in genome instability during the fetal stage, spontaneous mutations were studied in Mlh1-deficient lacZ-transgenic mouse fetuses. Mutation levels were high at 9.5 days post coitum (dpc) and gradually increased during the embryonic stage, after which they remained unchanged. In addition, mutations that were found in brain, liver, spleen, small intestine and...

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Source

Identifiers

PMID: 27643877
DOI: 10.1667/RR14454.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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